Assay Detail
Functional
CHEMBL2185240
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Agonist activity at rat 5HT4S receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.07 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | 1.0 | 1 | 9.23 |
| CHEMBL2179583 | — | — | 1 | 9.05 |
| CHEMBL2179582 | PF-03382792 | 1.0 | 1 | 8.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | EC50 | = | 0.59 | nM | 9.23 |
| CHEMBL2179583 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2179582 | PF-03382792 | EC50 | = | 1.15 | nM | 8.94 |