5-hydroxytryptamine receptor 4 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q62758. Use UniProt Q62758 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q62758 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 4
Review this target as 5-hydroxytryptamine receptor 4, mapped to UniProt Q62758. Sequence length is 406 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 4 as ChEMBL target CHEMBL4317, mapped to UniProt Q62758. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 5-hydroxytryptamine receptor 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q62758 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 4 |
| UniProt Accession | Q62758 |
| Component Type | Protein |
| Sequence Length | 406 aa |
5-hydroxytryptamine receptor 4
Review this target as 5-hydroxytryptamine receptor 4, mapped to UniProt Q62758. Sequence length is 406 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3126108 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL3221572 | 10.09 | Ki | 0.081 | Preclinical |
| CHEMBL329487 | 9.96 | Ki | 0.1096 | Preclinical |
| CHEMBL315071 | 9.89 | Ki | 0.13 | Preclinical |
| CHEMBL3221571 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL33884 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL3126109 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL155917 | 9.59 | Ki | 0.26 | Preclinical |
| CHEMBL50660 | 9.59 | Ki | 0.26 | Preclinical |
| CHEMBL262950 | 9.54 | Ki | 0.2884 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 21 | 36 | 7.2 |
| tissue-based format | 13 | 26 | 7.3 |
| cell-based format | 11 | 4 | 8.8 |
| organism-based format | 6 | 0 | — |
| single protein format | 2 | 1 | 7.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 13 | 93 | 7.9 |
| single protein format | 13 | 14 | 6.8 |
| tissue-based format | 9 | 33 | 7.3 |
| assay format | 4 | 19 | 7.2 |
| cell-based format | 3 | 3 | 8.0 |