Assay Detail
Functional
CHEMBL2185458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl H396R mutant after 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.63 | 8.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 8.76 |
| CHEMBL2177645 | — | — | 1 | 8.43 |
| CHEMBL2178277 | — | — | 1 | 8.27 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 7.06 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 1.72 | nM | 8.76 |
| CHEMBL2177645 | — | IC50 | = | 3.73 | nM | 8.43 |
| CHEMBL2178277 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 87.2 | nM | 7.06 |
| CHEMBL941 | IMATINIB | IC50 | = | 2377.0 | nM | 5.62 |