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Assay Detail

CHEMBL2185490

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human LNCAP cells incubated for 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LNCaP
Confidence 1 — Organism
Curated By Autocuration

Target

LNCaP (CHEMBL612518)
Type CELL-LINE
Organism Homo sapiens

Publication

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ.
J Med Chem (2012) 55 : 9492 -9509
PubMed 23098137 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.18 5.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2177139 1 5.35
CHEMBL2180584 1 5.30
CHEMBL2180574 1 5.30
CHEMBL2180582 1 5.22
CHEMBL2180579 1 5.16
CHEMBL2180559 1 5.10
CHEMBL2180580 1 5.10
CHEMBL2180578 1 5.10
CHEMBL2180576 1 5.10
CHEMBL2180575 1 5.10
CHEMBL2180558 1 -
CHEMBL2180583 1 -
CHEMBL2180581 1 -
CHEMBL2180577 1 -
CHEMBL2180573 1 -
CHEMBL2180598 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2177139 IC50 = 4500.0 nM 5.35
CHEMBL2180584 IC50 = 5000.0 nM 5.30
CHEMBL2180574 IC50 = 5000.0 nM 5.30
CHEMBL2180582 IC50 = 6000.0 nM 5.22
CHEMBL2180579 IC50 = 7000.0 nM 5.16
CHEMBL2180559 IC50 = 8000.0 nM 5.10
CHEMBL2180580 IC50 = 8000.0 nM 5.10
CHEMBL2180578 IC50 = 8000.0 nM 5.10
CHEMBL2180576 IC50 = 8000.0 nM 5.10
CHEMBL2180575 IC50 = 8000.0 nM 5.10
CHEMBL2180558 IC50 - -
CHEMBL2180583 IC50 > 10000.0 nM -
CHEMBL2180581 IC50 > 10000.0 nM -
CHEMBL2180577 IC50 > 10000.0 nM -
CHEMBL2180573 IC50 > 10000.0 nM -
CHEMBL2180598 IC50 - -