Assay Detail
Functional
CHEMBL2185494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against p53 expressing human HCT116 cells incubated for 72 hrs by MTT assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.24 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414850 | — | — | 1 | 5.70 |
| CHEMBL2180246 | — | — | 1 | 5.70 |
| CHEMBL2180561 | — | — | 1 | 5.52 |
| CHEMBL2180586 | — | — | 1 | 5.52 |
| CHEMBL2180567 | — | — | 1 | 5.40 |
| CHEMBL2180587 | — | — | 1 | 5.40 |
| CHEMBL2180568 | — | — | 1 | 5.22 |
| CHEMBL2180565 | — | — | 1 | 5.22 |
| CHEMBL2180249 | — | — | 1 | 5.19 |
| CHEMBL2180560 | — | — | 1 | 5.16 |
| CHEMBL2180578 | — | — | 1 | 5.16 |
| CHEMBL2180584 | — | — | 1 | 5.16 |
| CHEMBL2180562 | — | — | 1 | 5.16 |
| CHEMBL2180558 | — | — | 1 | 5.10 |
| CHEMBL2180245 | — | — | 1 | 5.06 |
| CHEMBL2180575 | — | — | 1 | 5.05 |
| CHEMBL2180582 | — | — | 1 | 5.04 |
| CHEMBL2180579 | — | — | 1 | 5.00 |
| CHEMBL2180585 | — | — | 1 | 4.82 |
| CHEMBL2180571 | — | — | 1 | - |
| CHEMBL2180588 | — | — | 1 | - |
| CHEMBL2180598 | — | — | 1 | - |
| CHEMBL2180597 | — | — | 1 | - |
| CHEMBL2180596 | — | — | 1 | - |
| CHEMBL2180595 | — | — | 1 | - |
| CHEMBL2180600 | — | — | 1 | - |
| CHEMBL2180594 | — | — | 1 | - |
| CHEMBL2180593 | — | — | 1 | - |
| CHEMBL2180592 | — | — | 1 | - |
| CHEMBL2180591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414850 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2180246 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2180561 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2180586 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2180567 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2180587 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2180568 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2180565 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2180249 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2180560 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2180578 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2180584 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2180562 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2180558 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2180245 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL2180575 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2180582 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2180579 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2180585 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2180577 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180580 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180581 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180583 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2177139 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180572 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180564 | — | IC50 | - | — | - | |
| CHEMBL2180566 | — | IC50 | - | — | - | |
| CHEMBL2180569 | — | IC50 | - | — | - | |
| CHEMBL2180570 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180243 | — | IC50 | - | — | - | |
| CHEMBL2180244 | — | IC50 | - | — | - | |
| CHEMBL2180247 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180248 | — | IC50 | - | — | - | |
| CHEMBL2180559 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180589 | — | IC50 | - | — | - | |
| CHEMBL2180601 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180599 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180590 | — | IC50 | - | — | - | |
| CHEMBL2180591 | — | IC50 | - | — | - | |
| CHEMBL2180592 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180593 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180594 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180600 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180595 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180596 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180597 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180598 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180588 | — | IC50 | - | — | - | |
| CHEMBL2180571 | — | IC50 | > | 20000.0 | nM | - |