Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2185495

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against p53 deficient human HCT116 cells incubated for 72 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ.
J Med Chem (2012) 55 : 9492 -9509
PubMed 23098137 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 5.21 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414850 1 5.70
CHEMBL2180584 1 5.40
CHEMBL2180586 1 5.40
CHEMBL2180582 1 5.22
CHEMBL2180587 1 5.22
CHEMBL2180585 1 5.16
CHEMBL2180579 1 5.16
CHEMBL2180558 1 5.07
CHEMBL2180581 1 5.05
CHEMBL2180598 1 4.75
CHEMBL2180590 1 -
CHEMBL2180591 1 -
CHEMBL2180592 1 -
CHEMBL2180577 1 -
CHEMBL2180594 1 -
CHEMBL2180595 1 -
CHEMBL2180596 1 -
CHEMBL2180597 1 -
CHEMBL2180559 1 -
CHEMBL2180571 1 -
CHEMBL2180589 1 -
CHEMBL2180588 1 -
CHEMBL2180578 1 -
CHEMBL2180580 1 -
CHEMBL2180583 1 -
CHEMBL2177139 1 -
CHEMBL2180601 1 -
CHEMBL2180600 1 -
CHEMBL2180599 1 -
CHEMBL2180593 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414850 IC50 = 2000.0 nM 5.70
CHEMBL2180584 IC50 = 4000.0 nM 5.40
CHEMBL2180586 IC50 = 4000.0 nM 5.40
CHEMBL2180582 IC50 = 6000.0 nM 5.22
CHEMBL2180587 IC50 = 6000.0 nM 5.22
CHEMBL2180585 IC50 = 7000.0 nM 5.16
CHEMBL2180579 IC50 = 7000.0 nM 5.16
CHEMBL2180558 IC50 = 8500.0 nM 5.07
CHEMBL2180581 IC50 = 9000.0 nM 5.05
CHEMBL2180598 IC50 = 18000.0 nM 4.75
CHEMBL2180577 IC50 > 10000.0 nM -
CHEMBL2180576 IC50 > 10000.0 nM -
CHEMBL2180594 IC50 > 20000.0 nM -
CHEMBL2180595 IC50 > 20000.0 nM -
CHEMBL2180596 IC50 > 20000.0 nM -
CHEMBL2180597 IC50 > 20000.0 nM -
CHEMBL2180559 IC50 > 10000.0 nM -
CHEMBL2180571 IC50 > 20000.0 nM -
CHEMBL2180572 IC50 > 20000.0 nM -
CHEMBL2180573 IC50 > 10000.0 nM -
CHEMBL2180574 IC50 > 10000.0 nM -
CHEMBL2180575 IC50 > 10000.0 nM -
CHEMBL2180592 IC50 > 20000.0 nM -
CHEMBL2180591 IC50 - -
CHEMBL2180590 IC50 - -
CHEMBL2180589 IC50 - -
CHEMBL2180588 IC50 - -
CHEMBL2180578 IC50 > 10000.0 nM -
CHEMBL2180580 IC50 > 10000.0 nM -
CHEMBL2180583 IC50 > 10000.0 nM -
CHEMBL2177139 IC50 > 10000.0 nM -
CHEMBL2180601 IC50 > 20000.0 nM -
CHEMBL2180600 IC50 > 20000.0 nM -
CHEMBL2180599 IC50 > 20000.0 nM -
CHEMBL2180593 IC50 > 20000.0 nM -