Assay Detail
Binding
CHEMBL2185667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]GR113808 from 5HT4 receptor in rat striatal membrane after 30 mins by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.92 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | 1.0 | 1 | 9.52 |
| CHEMBL2179583 | — | — | 1 | 8.82 |
| CHEMBL2179582 | PF-03382792 | 1.0 | 1 | 8.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2179583 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2179582 | PF-03382792 | Ki | = | 3.9 | nM | 8.41 |