Assay Detail
Functional
CHEMBL2185684
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Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.92 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179580 | — | — | 1 | 9.40 |
| CHEMBL2179584 | — | — | 1 | 9.10 |
| CHEMBL2179583 | — | — | 1 | 9.05 |
| CHEMBL2179582 | PF-03382792 | 1.0 | 1 | 9.05 |
| CHEMBL2179589 | — | — | 1 | 9.01 |
| CHEMBL2179586 | — | — | 1 | 8.96 |
| CHEMBL2179587 | — | — | 1 | 8.92 |
| CHEMBL2179585 | — | — | 1 | 8.92 |
| CHEMBL2179590 | — | — | 1 | 8.77 |
| CHEMBL2179581 | — | — | 1 | 8.72 |
| CHEMBL2179588 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179580 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2179584 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2179583 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2179582 | PF-03382792 | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2179589 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL2179586 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2179587 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2179585 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2179590 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2179581 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2179588 | — | EC50 | = | 6.3 | nM | 8.20 |