Compound Detail
CHEMBL2179589
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Basic Information
| ChEMBL ID | CHEMBL2179589 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CBAXDQOODLLERS-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
418.5
MW (Da)
3.49
ALogP
7
HBA
1
HBD
77.2
PSA (Ų)
0.70
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.01
Ki 1 meas. best 9.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | Ki | 9.44 | 9.44 | 0.4 | 1 |
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | EC50 | 9.01 | 9.01 | 1.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 72.0 | mL.min-1.kg-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Ki | = | 0.36 | nM | 9.44 | Displacement of [3H]GR113808 from human 5HT4D receptor expressed in HEK293 cells... | 22974325 |
| 5-hydroxytryptamine receptor 4 | EC50 | = | 0.98 | nM | 9.01 | Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as c... | 22974325 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22974325 | 10.1021/jm300953p | 5-hydroxytryptamine receptor 4 | 3 |
| 22974325 | 10.1021/jm300953p | Liver microsomes | 1 |
| 22974325 | 10.1021/jm300953p | Cytochrome P450 2D6 | 1 |
| 22974325 | 10.1021/jm300953p | ADMET | 1 |
Data from ChEMBL 36 via Core Engine