Assay Detail
Binding
CHEMBL2185685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]GR113808 from human 5HT4D receptor expressed in HEK293 cells after 30 mins by liquid scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.02 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | 1.0 | 1 | 9.82 |
| CHEMBL2179584 | — | — | 1 | 9.57 |
| CHEMBL2179587 | — | — | 1 | 9.54 |
| CHEMBL2179589 | — | — | 1 | 9.44 |
| CHEMBL2179580 | — | — | 1 | 9.30 |
| CHEMBL2179585 | — | — | 1 | 9.13 |
| CHEMBL2179586 | — | — | 1 | 9.01 |
| CHEMBL2179583 | — | — | 1 | 8.77 |
| CHEMBL2179582 | PF-03382792 | 1.0 | 1 | 8.57 |
| CHEMBL2179590 | — | — | 1 | 8.44 |
| CHEMBL2179581 | — | — | 1 | 8.35 |
| CHEMBL2179588 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152922 | PF-04995274 | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL2179584 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL2179587 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL2179589 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL2179580 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2179585 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL2179586 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL2179583 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2179582 | PF-03382792 | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL2179590 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL2179581 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL2179588 | — | Ki | = | 5.2 | nM | 8.28 |