Assay Detail
Functional
CHEMBL2185783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 3B infected in C8166 cells assessed as virus-induced cytopathic effect measuring scintia formation after 3 days by microscopy
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.69 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.06 |
| CHEMBL1935203 | — | — | 1 | 5.74 |
| CHEMBL243619 | — | — | 1 | 4.53 |
| CHEMBL301567 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1935203 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL243619 | — | EC50 | = | 29620.0 | nM | 4.53 |
| CHEMBL301567 | — | EC50 | = | 36590.0 | nM | 4.44 |