Assay Detail
Binding
CHEMBL2185837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha in human PC3 cells assessed as reduction in pAKT level by immunoblotting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.29 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178608 | — | — | 1 | 7.52 |
| CHEMBL2178606 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178608 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2178606 | — | IC50 | = | 90.0 | nM | 7.05 |