Assay Detail
Functional
CHEMBL2186432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against trypomastigote form of Trypanosoma brucei rhodesiense STIB 900 assessed as growth inhibition after 72 hrs by microplate fluorometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.00 |
| CHEMBL255731 | — | — | 1 | 7.30 |
| CHEMBL2179000 | — | — | 1 | 7.16 |
| CHEMBL256155 | — | — | 1 | 7.10 |
| CHEMBL2178998 | — | — | 1 | 6.66 |
| CHEMBL2179006 | — | — | 1 | 6.64 |
| CHEMBL2179005 | — | — | 1 | 6.62 |
| CHEMBL2178999 | — | — | 1 | 6.58 |
| CHEMBL2179004 | — | — | 1 | 6.50 |
| CHEMBL2177124 | — | — | 1 | 6.46 |
| CHEMBL2179001 | — | — | 1 | 6.35 |
| CHEMBL2179002 | — | — | 1 | 6.34 |
| CHEMBL2179003 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL255731 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2179000 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL256155 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2178998 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2179006 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2179005 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2178999 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2179004 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2177124 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2179001 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2179002 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2179003 | — | IC50 | = | 720.0 | nM | 6.14 |