Assay Detail
Functional
CHEMBL2186854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 72 hrs by CCK-8 assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.31 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214141 | — | — | 1 | 8.21 |
| CHEMBL2178277 | — | — | 1 | 7.92 |
| CHEMBL2177645 | — | — | 1 | 7.86 |
| CHEMBL2178278 | — | — | 1 | 7.33 |
| CHEMBL2177642 | — | — | 1 | 7.17 |
| CHEMBL2177646 | — | — | 1 | 7.10 |
| CHEMBL2177648 | — | — | 1 | 7.04 |
| CHEMBL2178276 | — | — | 1 | 6.89 |
| CHEMBL2177632 | — | — | 1 | 6.75 |
| CHEMBL2178279 | — | — | 1 | 6.55 |
| CHEMBL2178268 | — | — | 1 | 6.53 |
| CHEMBL2177634 | — | — | 1 | 6.52 |
| CHEMBL2177635 | — | — | 1 | 6.39 |
| CHEMBL2178271 | — | — | 1 | 6.33 |
| CHEMBL2177633 | — | — | 1 | 6.31 |
| CHEMBL2178270 | — | — | 1 | 6.28 |
| CHEMBL2177641 | — | — | 1 | 6.27 |
| CHEMBL2177649 | — | — | 1 | 6.26 |
| CHEMBL2177636 | — | — | 1 | 6.24 |
| CHEMBL2178274 | — | — | 1 | 6.21 |
| CHEMBL2178273 | — | — | 1 | 6.19 |
| CHEMBL2178272 | — | — | 1 | 6.18 |
| CHEMBL2178275 | — | — | 1 | 6.14 |
| CHEMBL2177644 | — | — | 1 | 6.12 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 6.11 |
| CHEMBL2177637 | — | — | 1 | 6.10 |
| CHEMBL2178269 | — | — | 1 | 6.06 |
| CHEMBL2177647 | — | — | 1 | 6.03 |
| CHEMBL2177643 | — | — | 1 | 6.00 |
| CHEMBL2178280 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214141 | — | IC50 | = | 6.18 | nM | 8.21 |
| CHEMBL2178277 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL2177645 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL2178278 | — | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL2177642 | — | IC50 | = | 66.9 | nM | 7.17 |
| CHEMBL2177646 | — | IC50 | = | 79.6 | nM | 7.10 |
| CHEMBL2177648 | — | IC50 | = | 91.7 | nM | 7.04 |
| CHEMBL2178276 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2177632 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL2178279 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL2178268 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL2177634 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL2177635 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL2178271 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL2177633 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL2178270 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL2177641 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL2177649 | — | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL2177636 | — | IC50 | = | 579.0 | nM | 6.24 |
| CHEMBL2178274 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2178273 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL2178272 | — | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL2178275 | — | IC50 | = | 728.0 | nM | 6.14 |
| CHEMBL2177644 | — | IC50 | = | 754.0 | nM | 6.12 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL2177637 | — | IC50 | = | 799.0 | nM | 6.10 |
| CHEMBL2178269 | — | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL2177647 | — | IC50 | = | 939.0 | nM | 6.03 |
| CHEMBL2177643 | — | IC50 | = | 999.0 | nM | 6.00 |
| CHEMBL2178280 | — | IC50 | = | 1156.0 | nM | 5.94 |
| CHEMBL2177631 | — | IC50 | = | 1444.0 | nM | 5.84 |
| CHEMBL2178267 | — | IC50 | = | 1557.0 | nM | 5.81 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 1714.0 | nM | 5.77 |
| CHEMBL2178281 | — | IC50 | = | 2062.0 | nM | 5.69 |
| CHEMBL941 | IMATINIB | IC50 | = | 3005.0 | nM | 5.52 |
| CHEMBL2177639 | — | IC50 | = | 3499.0 | nM | 5.46 |
| CHEMBL2177640 | — | IC50 | = | 3588.0 | nM | 5.45 |
| CHEMBL2177650 | — | IC50 | = | 3514.0 | nM | 5.45 |
| CHEMBL2177638 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL2177630 | — | IC50 | = | 8836.0 | nM | 5.05 |
| CHEMBL2177629 | — | IC50 | > | 10000.0 | nM | - |