Assay Detail
Functional
CHEMBL2186857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KU812 cells expressing wild type Bcr-Abl after 72 hrs by CCK-8 assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KU812 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 9.12 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178277 | — | — | 1 | 10.10 |
| CHEMBL1214141 | — | — | 1 | 10.10 |
| CHEMBL2178278 | — | — | 1 | 10.00 |
| CHEMBL2178276 | — | — | 1 | 10.00 |
| CHEMBL2177645 | — | — | 1 | 9.96 |
| CHEMBL2177642 | — | — | 1 | 9.85 |
| CHEMBL2177646 | — | — | 1 | 9.82 |
| CHEMBL2177632 | — | — | 1 | 9.80 |
| CHEMBL2177634 | — | — | 1 | 9.80 |
| CHEMBL2177647 | — | — | 1 | 9.72 |
| CHEMBL2177633 | — | — | 1 | 9.70 |
| CHEMBL2177635 | — | — | 1 | 9.70 |
| CHEMBL2177636 | — | — | 1 | 9.66 |
| CHEMBL2177649 | — | — | 1 | 9.62 |
| CHEMBL2178268 | — | — | 1 | 9.42 |
| CHEMBL2178279 | — | — | 1 | 9.41 |
| CHEMBL2178271 | — | — | 1 | 9.40 |
| CHEMBL2178274 | — | — | 1 | 9.40 |
| CHEMBL2178270 | — | — | 1 | 9.37 |
| CHEMBL2178267 | — | — | 1 | 9.34 |
| CHEMBL2178273 | — | — | 1 | 9.34 |
| CHEMBL2177650 | — | — | 1 | 9.33 |
| CHEMBL2177648 | — | — | 1 | 9.17 |
| CHEMBL2178272 | — | — | 1 | 9.14 |
| CHEMBL2178275 | — | — | 1 | 8.87 |
| CHEMBL2177637 | — | — | 1 | 8.84 |
| CHEMBL2178269 | — | — | 1 | 8.83 |
| CHEMBL2177631 | — | — | 1 | 8.82 |
| CHEMBL2177638 | — | — | 1 | 8.80 |
| CHEMBL2177639 | — | — | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178277 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1214141 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL2178276 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2178278 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2177645 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL2177642 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL2177646 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2177632 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2177634 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2177647 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL2177635 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2177633 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2177636 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL2177649 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL2178268 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL2178279 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL2178271 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2178274 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2178270 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL2178267 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL2178273 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL2177650 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL2177648 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL2178272 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL2178275 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL2177637 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL2178269 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL2177631 | — | IC50 | = | 1.51 | nM | 8.82 |
| CHEMBL2177638 | — | IC50 | = | 1.57 | nM | 8.80 |
| CHEMBL2177639 | — | IC50 | = | 1.89 | nM | 8.72 |
| CHEMBL2178280 | — | IC50 | = | 4.05 | nM | 8.39 |
| CHEMBL2177630 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2177641 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL2177644 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL2178281 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL2177629 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL2177643 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL2177640 | — | IC50 | = | 158.0 | nM | 6.80 |