Assay Detail
Functional
CHEMBL2186929
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Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.01 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 7.40 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | 7.30 |
| CHEMBL2181355 | — | — | 1 | 7.30 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 7.30 |
| CHEMBL2181556 | — | — | 1 | 6.89 |
| CHEMBL2181565 | — | — | 1 | 6.77 |
| CHEMBL2181376 | — | — | 1 | 6.68 |
| CHEMBL2181564 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2181355 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2181556 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2181565 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2181376 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2181564 | — | IC50 | = | 370.0 | nM | 6.43 |