Assay Detail
Functional
CHEMBL2186930
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Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.82 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181355 | — | — | 1 | 6.40 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 6.22 |
| CHEMBL2181565 | — | — | 1 | 5.92 |
| CHEMBL2181376 | — | — | 1 | 5.85 |
| CHEMBL2181556 | — | — | 1 | 5.85 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 5.60 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | 5.44 |
| CHEMBL2181564 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181355 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2181565 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2181376 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2181556 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2181564 | — | IC50 | = | 5800.0 | nM | 5.24 |