Assay Detail
Functional
CHEMBL2186944
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Cytostatic activity against thymidine-kinase deficient human CEM cells after 72 hrs by cell counting
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.26 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181364 | — | — | 1 | 6.72 |
| CHEMBL2181358 | — | — | 1 | 6.55 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 6.51 |
| CHEMBL2181359 | — | — | 1 | 6.19 |
| CHEMBL2181357 | — | — | 1 | 6.08 |
| CHEMBL2181361 | — | — | 1 | 6.04 |
| CHEMBL2181362 | — | — | 1 | 6.00 |
| CHEMBL2181366 | — | — | 1 | 6.00 |
| CHEMBL2181356 | — | — | 1 | 5.96 |
| CHEMBL2181365 | — | — | 1 | 5.96 |
| CHEMBL2181555 | — | — | 1 | 5.92 |
| CHEMBL2181360 | — | — | 1 | 5.82 |
| CHEMBL2181566 | — | — | 1 | 5.80 |
| CHEMBL2181355 | — | — | 1 | 5.62 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 5.52 |
| CHEMBL2181565 | — | — | 1 | 5.32 |
| CHEMBL2181354 | — | — | 1 | 5.27 |
| CHEMBL2181363 | — | — | 1 | 5.17 |
| CHEMBL2181376 | — | — | 1 | 5.16 |
| CHEMBL2181374 | — | — | 1 | 5.14 |
| CHEMBL2181373 | — | — | 1 | 5.08 |
| CHEMBL2181560 | — | — | 1 | 4.96 |
| CHEMBL2181375 | — | — | 1 | 4.96 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.92 |
| CHEMBL2181561 | — | — | 1 | 4.89 |
| CHEMBL2181553 | — | — | 1 | 4.85 |
| CHEMBL2181370 | — | — | 1 | 4.82 |
| CHEMBL2181558 | — | — | 1 | 4.80 |
| CHEMBL2181372 | — | — | 1 | 4.77 |
| CHEMBL2181564 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181364 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2181358 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2181359 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2181357 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL2181361 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2181362 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2181366 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2181356 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2181365 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2181555 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2181360 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2181566 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2181355 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2181565 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2181354 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2181363 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2181376 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2181374 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2181373 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2181375 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2181560 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2181561 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2181553 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2181370 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2181558 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2181372 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2181564 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2181556 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2181562 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2181563 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2181371 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2181559 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2181554 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2177147 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2046836 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2181368 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2181369 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL2181557 | — | IC50 | > | 250000.0 | nM | - |