Assay Detail
Functional
CHEMBL2186945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytostatic activity against human CEM/0 cells after 72 hrs by cell counting
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.68 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181358 | — | — | 1 | 7.82 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 7.66 |
| CHEMBL2181361 | — | — | 1 | 7.46 |
| CHEMBL2181364 | — | — | 1 | 7.28 |
| CHEMBL2181362 | — | — | 1 | 7.24 |
| CHEMBL2181365 | — | — | 1 | 7.23 |
| CHEMBL2181357 | — | — | 1 | 7.19 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 7.17 |
| CHEMBL2181370 | — | — | 1 | 7.15 |
| CHEMBL2181360 | — | — | 1 | 7.14 |
| CHEMBL2181359 | — | — | 1 | 7.10 |
| CHEMBL2181366 | — | — | 1 | 7.10 |
| CHEMBL2181374 | — | — | 1 | 7.00 |
| CHEMBL2181373 | — | — | 1 | 7.00 |
| CHEMBL2181368 | — | — | 1 | 6.96 |
| CHEMBL2181371 | — | — | 1 | 6.89 |
| CHEMBL2181356 | — | — | 1 | 6.85 |
| CHEMBL2181354 | — | — | 1 | 6.85 |
| CHEMBL2181355 | — | — | 1 | 6.80 |
| CHEMBL2181555 | — | — | 1 | 6.77 |
| CHEMBL2181556 | — | — | 1 | 6.75 |
| CHEMBL2181375 | — | — | 1 | 6.72 |
| CHEMBL2181565 | — | — | 1 | 6.64 |
| CHEMBL2181558 | — | — | 1 | 6.62 |
| CHEMBL2181566 | — | — | 1 | 6.60 |
| CHEMBL2181560 | — | — | 1 | 6.60 |
| CHEMBL2181562 | — | — | 1 | 6.55 |
| CHEMBL2181561 | — | — | 1 | 6.46 |
| CHEMBL2181376 | — | — | 1 | 6.44 |
| CHEMBL2181372 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181358 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2181361 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2181364 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2181362 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2181365 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2181357 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2181370 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2181360 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2181366 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2181359 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2181374 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2181373 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2181368 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2181371 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2181356 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2181354 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2181355 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2181555 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2181556 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2181375 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2181565 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2181558 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2181566 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2181560 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2181562 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2181561 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2181376 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2181372 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2181363 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2181564 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2046836 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2181369 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2177147 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2181553 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2181563 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2181557 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2181559 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2181554 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 18000.0 | nM | 4.75 |