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Assay Detail

CHEMBL2187072

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter
36
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A2a (CHEMBL251)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications.
Baraldi PG, Preti D, Borea PA, Varani K.
J Med Chem (2012) 55 : 5676 -5703
PubMed 22468757 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 35 6.29 7.80
IC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL186113 GW-328267 1.0 2 7.80
CHEMBL88147 1 7.60
CHEMBL332091 1 7.00
CHEMBL322250 1 6.92
CHEMBL2181971 1 6.84
CHEMBL122396 1 6.67
CHEMBL2181965 1 6.33
CHEMBL193692 1 6.29
CHEMBL198779 1 6.08
CHEMBL175543 1 5.64
CHEMBL2181970 1 5.62
CHEMBL193421 1 5.60
CHEMBL2181977 1 5.09
CHEMBL2181969 1 4.53
CHEMBL113420 1 -
CHEMBL123705 1 -
CHEMBL99178 1 -
CHEMBL211862 1 -
CHEMBL363419 1 -
CHEMBL589080 1 -
CHEMBL2181975 1 -
CHEMBL2181972 1 -
CHEMBL339066 1 -
CHEMBL398587 1 -
CHEMBL1625681 1 -
CHEMBL371404 1 -
CHEMBL188035 1 -
CHEMBL2181973 1 -
CHEMBL2181976 1 -
CHEMBL434534 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL186113 GW-328267 Ki = 16.0 nM 7.80
CHEMBL88147 Ki = 25.0 nM 7.60
CHEMBL332091 Ki = 100.0 nM 7.00
CHEMBL322250 Ki = 119.0 nM 6.92
CHEMBL2181971 Ki = 145.0 nM 6.84
CHEMBL122396 Ki = 214.0 nM 6.67
CHEMBL2181965 Ki = 470.0 nM 6.33
CHEMBL193692 Ki = 510.0 nM 6.29
CHEMBL198779 Ki = 833.0 nM 6.08
CHEMBL175543 Ki = 2300.0 nM 5.64
CHEMBL2181970 Ki = 2370.0 nM 5.62
CHEMBL193421 Ki = 2530.0 nM 5.60
CHEMBL2181977 Ki = 8050.0 nM 5.09
CHEMBL2181969 Ki = 29800.0 nM 4.53
CHEMBL2181966 Ki > 100000.0 nM -
CHEMBL2177153 Ki > 10000.0 nM -
CHEMBL2181968 Ki > 10000.0 nM -
CHEMBL2181967 Ki > 10000.0 nM -
CHEMBL2181964 Ki > 10000.0 nM -
CHEMBL113420 Ki > 10000.0 nM -
CHEMBL123705 Ki > 10000.0 nM -
CHEMBL99178 Ki > 10000.0 nM -
CHEMBL211862 Ki > 10000.0 nM -
CHEMBL363419 Ki > 10000.0 nM -
CHEMBL589080 Ki > 10000.0 nM -
CHEMBL2181975 Ki > 10000.0 nM -
CHEMBL2181972 Ki > 10000.0 nM -
CHEMBL339066 IC50 > 10000.0 nM -
CHEMBL398587 Ki > 5000.0 nM -
CHEMBL1625681 Ki > 1280.0 nM -
CHEMBL371404 Ki > 1000.0 nM -
CHEMBL188035 Ki > 1000.0 nM -
CHEMBL2181973 Ki > 1000.0 nM -
CHEMBL2181976 Ki > 826.0 nM -
CHEMBL434534 Ki > 1000.0 nM -
CHEMBL186113 GW-328267 Ki >= 1000.0 nM -