Assay Detail
Binding
CHEMBL2187138
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Binding affinity to Staphylococcus aureus FtsZ expressed in Escherichia coli BL21 (DE3) at 25 degC by fluorescence anisotropy assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.46 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180486 | — | — | 1 | 5.46 |
| CHEMBL2177138 | — | — | 1 | - |
| CHEMBL2180485 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180486 | — | Kd | = | 3500.0 | nM | 5.46 |
| CHEMBL2177138 | — | Kd | - | — | - | |
| CHEMBL2180485 | — | Kd | - | — | - |