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Target Snapshot

CHEMBL5096 Target Snapshot

Cell division protein FtsZ · SINGLE PROTEIN · Staphylococcus aureus

228Compounds
138Assays
1Approved Drugs
32.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P0A031. Use UniProt P0A031 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0A031 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cell division protein FtsZ as ChEMBL target CHEMBL5096, mapped to UniProt P0A031. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cell division protein FtsZ
SINGLE PROTEIN · Staphylococcus aureus
As of 2026-09-13
ChEMBL target ID
CHEMBL5096
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P0A031
Cell division protein FtsZ
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cell division protein FtsZ is the right protein anchor across sources, using UniProt P0A031 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCell division protein FtsZ
UniProt AccessionP0A031
Component TypeProtein
Sequence Length390 aa

Cell division protein FtsZ

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Cell division protein FtsZ, mapped to UniProt P0A031. Sequence length is 390 aa.

Mapped IDP0A031
Review nameCell division protein FtsZ
OrganismStaphylococcus aureus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5018.0
EC501.0
KD13.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL511201 6.82 IC50 150.0 Preclinical
CHEMBL5199894 6.22 Kd 600.0 Preclinical
CHEMBL2207296 5.7 Kd 2000.0 Preclinical
CHEMBL5188114 5.62 Kd 2380.0 Preclinical
CHEMBL5200927 5.6 Kd 2490.0 Preclinical
CHEMBL2180486 5.46 Kd 3500.0 Preclinical
CHEMBL5174791 5.42 Kd 3840.0 Preclinical
CHEMBL5186593 5.41 Kd 3860.0 Preclinical
CHEMBL511201 5.4 EC50 4000.0 Preclinical
CHEMBL2207300 5.27 Kd 5400.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
3
5.5
1
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

138
Total Assays
21
Tested Compounds
1
Assay Types
Binding — 138 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 93 14 5.0
assay format 36 5 4.7
cell-based format 9 2 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine