Compound Detail
CHEMBL5199894
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Basic Information
| ChEMBL ID | CHEMBL5199894 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTFCQSNTRJJDCY-JXMROGBWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
455.9
MW (Da)
5.11
ALogP
6
HBA
2
HBD
79.4
PSA (Ų)
0.50
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cell division protein FtsZ CHEMBL5096 | Kd | 6.22 | 6.22 | 600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cell division protein FtsZ | Kd | = | 600.0 | nM | 6.22 | Binding affinity to Staphylococcus aureus FtsZ assessed as dissociation constant... | 35224498 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35224498 | 10.1039/d1md00249j | Staphylococcus aureus | 12 |
| 35224498 | 10.1039/d1md00249j | Bacillus subtilis | 3 |
| 35224498 | 10.1039/d1md00249j | Cell division protein FtsZ | 3 |
| 35224498 | 10.1039/d1md00249j | Escherichia coli | 2 |
| 35224498 | 10.1039/d1md00249j | Unchecked | 1 |
| 35224498 | 10.1039/d1md00249j | HFF-1 | 1 |
| 35224498 | 10.1039/d1md00249j | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine