Assay Detail
Functional
CHEMBL2187565
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Immunosuppressive activity in ICR mouse B cells assessed as inhibition of LPS-stimulated cell proliferation after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.06 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178112 | — | — | 1 | 5.75 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 5.39 |
| CHEMBL2178108 | — | — | 1 | 5.33 |
| CHEMBL2178105 | — | — | 1 | 5.06 |
| CHEMBL2178111 | — | — | 1 | 5.00 |
| CHEMBL2178107 | — | — | 1 | 4.95 |
| CHEMBL2178106 | — | — | 1 | 4.95 |
| CHEMBL2177115 | — | — | 1 | 4.88 |
| CHEMBL2178104 | — | — | 1 | 4.85 |
| CHEMBL1373924 | — | — | 1 | 4.79 |
| CHEMBL2178109 | — | — | 1 | 4.70 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | - |
| CHEMBL1076869 | — | — | 1 | - |
| CHEMBL2178110 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178112 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL2178108 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL2178105 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL2178111 | — | IC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL2178107 | — | IC50 | = | 11320.0 | nM | 4.95 |
| CHEMBL2178106 | — | IC50 | = | 11210.0 | nM | 4.95 |
| CHEMBL2177115 | — | IC50 | = | 13020.0 | nM | 4.88 |
| CHEMBL2178104 | — | IC50 | = | 14040.0 | nM | 4.85 |
| CHEMBL1373924 | — | IC50 | = | 16120.0 | nM | 4.79 |
| CHEMBL2178109 | — | IC50 | = | 19850.0 | nM | 4.70 |
| CHEMBL160 | CYCLOSPORINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1076869 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2178110 | — | IC50 | > | 100000.0 | nM | - |