Assay Detail
Binding
CHEMBL2187828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PDE2A expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf21 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Current landscape of phosphodiesterase 10A (PDE10A) inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.31 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180771 | — | — | 1 | 8.48 |
| CHEMBL2180772 | — | — | 1 | 8.28 |
| CHEMBL2180773 | — | — | 1 | 8.03 |
| CHEMBL2069321 | — | — | 1 | 7.52 |
| CHEMBL2180774 | — | — | 1 | 7.41 |
| CHEMBL2180775 | — | — | 1 | 7.09 |
| CHEMBL1086110 | — | — | 1 | 6.62 |
| CHEMBL2070666 | — | — | 1 | 6.46 |
| CHEMBL2070659 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180771 | — | IC50 | = | 3.31 | nM | 8.48 |
| CHEMBL2180772 | — | IC50 | = | 5.31 | nM | 8.28 |
| CHEMBL2180773 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL2069321 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL2180774 | — | IC50 | = | 39.4 | nM | 7.41 |
| CHEMBL2180775 | — | IC50 | = | 80.6 | nM | 7.09 |
| CHEMBL1086110 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL2070666 | — | IC50 | = | 346.5 | nM | 6.46 |
| CHEMBL2070659 | — | IC50 | = | 1150.0 | nM | 5.94 |