cGMP-dependent 3',5'-cyclic phosphodiesterase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O00408. Use UniProt O00408 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O00408 as the stable identity anchor, then attach disease evidence before program review.
cGMP-dependent 3',5'-cyclic phosphodiesterase
Review this target as cGMP-dependent 3',5'-cyclic phosphodiesterase, mapped to UniProt O00408. Sequence length is 941 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cGMP-dependent 3',5'-cyclic phosphodiesterase as ChEMBL target CHEMBL2652, mapped to UniProt O00408. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | cGMP-dependent 3',5'-cyclic phosphodiesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O00408 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cGMP-dependent 3',5'-cyclic phosphodiesterase |
| UniProt Accession | O00408 |
| Component Type | Protein |
| Sequence Length | 941 aa |
cGMP-dependent 3',5'-cyclic phosphodiesterase
Review this target as cGMP-dependent 3',5'-cyclic phosphodiesterase, mapped to UniProt O00408. Sequence length is 941 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5827044 | 10.8 | Ki | 0.016 | Preclinical |
| CHEMBL5773913 | 10.77 | Ki | 0.017 | Preclinical |
| CHEMBL6019094 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL5867733 | 10.66 | Ki | 0.022 | Preclinical |
| CHEMBL6027642 | 10.62 | Ki | 0.024 | Preclinical |
| CHEMBL370962 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL5948981 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL6040588 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL5847109 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL6032923 | 10.42 | Ki | 0.038 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 210 | 1,035 | 6.7 |
| cell-based format | 52 | 577 | 7.3 |
| assay format | 39 | 1,160 | 8.0 |
| tissue-based format | 3 | 17 | 4.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 11 | 4.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 11 | 5.5 |
| cell-based format | 3 | 0 | — |