Assay Detail
Binding
CHEMBL2187864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bacillus anthracis Protective antigen-mediated cytotoxicity in RAW264.7 cells compound co-treated for 5 hrs with antigen measured after 48 hrs by MTT assay in presence of FP59
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179142 | — | — | 1 | 6.00 |
| CHEMBL2179141 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179142 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2179141 | — | EC50 | = | 1000.0 | nM | 6.00 |