Assay Detail
Binding
CHEMBL2188280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain membranes
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The effect of Pro(2) modifications on the structural and pharmacological properties of endomorphin-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 7 | - | - |
| Ki | 7 | 7.51 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178089 | — | — | 2 | 8.89 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 2 | 8.85 |
| CHEMBL2178087 | — | — | 2 | 8.59 |
| CHEMBL1253632 | — | — | 2 | 7.57 |
| CHEMBL2178090 | — | — | 2 | 7.36 |
| CHEMBL2178088 | — | — | 2 | 5.67 |
| CHEMBL2178086 | — | — | 2 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178089 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2178087 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL1253632 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL2178090 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL2178088 | — | Ki | = | 2158.0 | nM | 5.67 |
| CHEMBL2178086 | — | Ki | = | 2299.0 | nM | 5.64 |
| CHEMBL2178086 | — | Activity | - | — | - | |
| CHEMBL2178087 | — | Activity | - | — | - | |
| CHEMBL2178088 | — | Activity | - | — | - | |
| CHEMBL2178089 | — | Activity | - | — | - | |
| CHEMBL1253632 | — | Activity | - | — | - | |
| CHEMBL2178090 | — | Activity | - | — | - | |
| CHEMBL333357 | ENDOMORPHIN 2 | Activity | - | — | - |