Assay Detail
Functional
CHEMBL2188545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human H1299 cells after 3 days by MTS assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.93 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181285 | — | — | 1 | 8.00 |
| CHEMBL393417 | DEGUELIN | — | 1 | 6.96 |
| CHEMBL2181292 | — | — | 1 | 6.96 |
| CHEMBL2181268 | — | — | 1 | 6.85 |
| CHEMBL2177146 | — | — | 1 | 6.85 |
| CHEMBL2181294 | — | — | 1 | 6.52 |
| CHEMBL2181280 | — | — | 1 | 6.31 |
| CHEMBL2181291 | — | — | 1 | 6.17 |
| CHEMBL2181277 | — | — | 1 | 6.14 |
| CHEMBL2181281 | — | — | 1 | 6.06 |
| CHEMBL2181282 | — | — | 1 | 6.01 |
| CHEMBL2181276 | — | — | 1 | 6.00 |
| CHEMBL2181265 | — | — | 1 | 5.89 |
| CHEMBL2181278 | — | — | 1 | 5.50 |
| CHEMBL2181275 | — | — | 1 | 5.42 |
| CHEMBL2181286 | — | — | 1 | 5.39 |
| CHEMBL2181284 | — | — | 1 | 5.38 |
| CHEMBL2181266 | — | — | 1 | 5.37 |
| CHEMBL2181274 | — | — | 1 | 5.35 |
| CHEMBL2181270 | ROTENONIC ACID, METHYL ETHER | — | 1 | 5.28 |
| CHEMBL2181295 | ROTENONIC ACID | — | 1 | 5.01 |
| CHEMBL2181287 | — | — | 1 | 5.01 |
| CHEMBL2181283 | — | — | 1 | 5.00 |
| CHEMBL2181288 | — | — | 1 | 4.98 |
| CHEMBL465673 | DEHYDRODEGUELIN | — | 1 | - |
| CHEMBL2181290 | — | — | 1 | - |
| CHEMBL2181279 | — | — | 1 | - |
| CHEMBL2181289 | — | — | 1 | - |
| CHEMBL2181293 | — | — | 1 | - |
| CHEMBL2181267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181285 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL393417 | DEGUELIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2181292 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2181268 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2177146 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2181294 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2181280 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2181291 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2181277 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2181281 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2181282 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2181276 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2181265 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2181278 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2181275 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2181286 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2181284 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2181266 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2181274 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2181270 | ROTENONIC ACID, METHYL ETHER | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2181295 | ROTENONIC ACID | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2181287 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2181283 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL2181288 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL465673 | DEHYDRODEGUELIN | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181290 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181279 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL2181289 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181293 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181267 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181269 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181271 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181272 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2181273 | — | IC50 | > | 500000.0 | nM | - |