Assay Detail
ADMET
CHEMBL2188593
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Cytotoxicity against human skin fibroblasts cells after 48 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.88 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180855 | — | — | 1 | 6.40 |
| CHEMBL2180854 | — | — | 1 | 6.30 |
| CHEMBL2180862 | — | — | 1 | 6.05 |
| CHEMBL2180863 | — | — | 1 | 5.62 |
| CHEMBL2180844 | — | — | 1 | 5.52 |
| CHEMBL2180849 | — | — | 1 | 5.40 |
| CHEMBL2180852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180855 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2180854 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2180862 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2180863 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL2180844 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2180849 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2180852 | — | IC50 | > | 25000.0 | nM | - |