Assay Detail
Binding
CHEMBL2188628
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Binding affinity to tabun-human AChE complex
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 4.81 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181434 | — | — | 1 | 5.40 |
| CHEMBL2181432 | — | — | 1 | 5.25 |
| CHEMBL2181430 | — | — | 1 | 5.16 |
| CHEMBL2181433 | — | — | 1 | 4.85 |
| CHEMBL2181431 | — | — | 1 | 4.57 |
| CHEMBL2181438 | — | — | 1 | 4.29 |
| CHEMBL2181437 | — | — | 1 | 4.12 |
| CHEMBL32778 | TRIMEDOXIME | 2.0 | 1 | - |
| CHEMBL2181429 | — | — | 1 | - |
| CHEMBL291233 | OBIDOXIME CHLORIDE | 2.0 | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181434 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL2181432 | — | Kd | = | 5600.0 | nM | 5.25 |
| CHEMBL2181430 | — | Kd | = | 7000.0 | nM | 5.16 |
| CHEMBL2181433 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL2181431 | — | Kd | = | 27000.0 | nM | 4.57 |
| CHEMBL2181438 | — | Kd | = | 51000.0 | nM | 4.29 |
| CHEMBL2181437 | — | Kd | = | 75000.0 | nM | 4.12 |
| CHEMBL32778 | TRIMEDOXIME | Kd | = | 145000.0 | nM | - |
| CHEMBL2181429 | — | Kd | = | 106000.0 | nM | - |
| CHEMBL291233 | OBIDOXIME CHLORIDE | Kd | = | 250000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | Kd | = | 706000.0 | nM | - |