Assay Detail
Binding
CHEMBL2188629
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Binding affinity to VX-human AChE complex
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 4.50 | 5.22 |
| Kd(app) | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181432 | — | — | 1 | 5.22 |
| CHEMBL2181429 | — | — | 1 | 5.11 |
| CHEMBL2181431 | — | — | 1 | 4.48 |
| CHEMBL2181433 | — | — | 1 | 4.42 |
| CHEMBL33051 | — | — | 1 | 4.30 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | 2.0 | 1 | 4.27 |
| CHEMBL2181439 | — | — | 1 | 4.11 |
| CHEMBL2181438 | — | — | 1 | 4.10 |
| CHEMBL2181440 | — | — | 1 | - |
| CHEMBL2181437 | — | — | 1 | - |
| CHEMBL2181436 | — | — | 1 | - |
| CHEMBL2181435 | — | — | 1 | - |
| CHEMBL2181434 | — | — | 1 | - |
| CHEMBL2181430 | — | — | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181432 | — | Kd | = | 6000.0 | nM | 5.22 |
| CHEMBL2181429 | — | Kd | = | 7800.0 | nM | 5.11 |
| CHEMBL2181431 | — | Kd | = | 33000.0 | nM | 4.48 |
| CHEMBL2181433 | — | Kd | = | 38000.0 | nM | 4.42 |
| CHEMBL33051 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | Kd | = | 54000.0 | nM | 4.27 |
| CHEMBL2181439 | — | Kd | = | 77000.0 | nM | 4.11 |
| CHEMBL2181438 | — | Kd | = | 79000.0 | nM | 4.10 |
| CHEMBL2181440 | — | Kd(app) | - | — | - | |
| CHEMBL2181437 | — | Kd | = | 113000.0 | nM | - |
| CHEMBL2181436 | — | Kd | = | 350000.0 | nM | - |
| CHEMBL2181435 | — | Kd(app) | - | — | - | |
| CHEMBL2181434 | — | Kd(app) | - | — | - | |
| CHEMBL2181430 | — | Kd | = | 117000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | Kd | = | 215000.0 | nM | - |