Assay Detail
Functional
CHEMBL2188651
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Agonist activity at mu opioid receptor in guinea pig ileum
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.54 | 9.51 |
| IC35 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181200 | — | — | 1 | 9.51 |
| CHEMBL2181195 | — | — | 1 | 9.19 |
| CHEMBL2181199 | — | — | 1 | 9.05 |
| CHEMBL2181196 | — | — | 1 | 9.00 |
| CHEMBL2181202 | — | — | 1 | 8.85 |
| CHEMBL2181193 | — | — | 1 | 8.84 |
| CHEMBL2181201 | — | — | 1 | 8.66 |
| CHEMBL2181197 | — | — | 1 | 8.36 |
| CHEMBL2181198 | — | — | 1 | 8.08 |
| CHEMBL2181192 | — | — | 1 | 7.31 |
| CHEMBL2181194 | — | — | 1 | 7.12 |
| CHEMBL2181191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181200 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL2181195 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL2181199 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL2181196 | — | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL2181202 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL2181193 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL2181201 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2181197 | — | IC50 | = | 4.35 | nM | 8.36 |
| CHEMBL2181198 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL2181192 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2181194 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2181191 | — | IC35 | = | 0.78 | nM | - |