Assay Detail
Binding
CHEMBL2188840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MK-801 from NMDAR in Sprague-Dawley rat cerebral cortex homogenates after 2 hrs by liquid scintillation counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.42 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 5.94 |
| CHEMBL2178782 | — | — | 1 | 5.63 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 5.51 |
| CHEMBL2178784 | MEMAGAL | — | 1 | 5.34 |
| CHEMBL2178787 | — | — | 1 | 5.33 |
| CHEMBL2178786 | — | — | 1 | 5.30 |
| CHEMBL2178778 | — | — | 1 | 5.27 |
| CHEMBL2178785 | — | — | 1 | 5.00 |
| CHEMBL2178780 | — | — | 1 | - |
| CHEMBL2178779 | — | — | 1 | - |
| CHEMBL2178777 | — | — | 1 | - |
| CHEMBL2178776 | — | — | 1 | - |
| CHEMBL2178791 | — | — | 1 | - |
| CHEMBL2178790 | — | — | 1 | - |
| CHEMBL2178789 | — | — | 1 | - |
| CHEMBL2178783 | — | — | 1 | - |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | - |
| CHEMBL2178788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL2178782 | — | Ki | = | 2320.0 | nM | 5.63 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 3080.0 | nM | 5.51 |
| CHEMBL2178784 | MEMAGAL | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL2178787 | — | Ki | = | 4630.0 | nM | 5.33 |
| CHEMBL2178786 | — | Ki | = | 4990.0 | nM | 5.30 |
| CHEMBL2178778 | — | Ki | = | 5410.0 | nM | 5.27 |
| CHEMBL2178785 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL2178780 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2178779 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2178777 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2178776 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2178791 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2178790 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2178789 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2178783 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL659 | GALANTAMINE | Ki | > | 10000.0 | nM | - |
| CHEMBL2178788 | — | Ki | > | 10000.0 | nM | - |