Assay Detail
Binding
CHEMBL2188841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.63 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178790 | — | — | 1 | 9.28 |
| CHEMBL2178788 | — | — | 1 | 8.99 |
| CHEMBL2178784 | MEMAGAL | — | 1 | 8.94 |
| CHEMBL2178789 | — | — | 1 | 8.88 |
| CHEMBL2178785 | — | — | 1 | 8.75 |
| CHEMBL2178787 | — | — | 1 | 8.63 |
| CHEMBL2178783 | — | — | 1 | 8.37 |
| CHEMBL2178786 | — | — | 1 | 8.27 |
| CHEMBL2178781 | — | — | 1 | 7.95 |
| CHEMBL2178779 | — | — | 1 | 7.25 |
| CHEMBL2178791 | — | — | 1 | 7.09 |
| CHEMBL2178777 | — | — | 1 | 6.88 |
| CHEMBL2178778 | — | — | 1 | 6.78 |
| CHEMBL2178780 | — | — | 1 | 6.43 |
| CHEMBL2178782 | — | — | 1 | 6.16 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.59 |
| CHEMBL2178776 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178790 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL2178788 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL2178784 | MEMAGAL | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL2178789 | — | IC50 | = | 1.33 | nM | 8.88 |
| CHEMBL2178785 | — | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL2178787 | — | IC50 | = | 2.32 | nM | 8.63 |
| CHEMBL2178783 | — | IC50 | = | 4.31 | nM | 8.37 |
| CHEMBL2178786 | — | IC50 | = | 5.36 | nM | 8.27 |
| CHEMBL2178781 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL2178779 | — | IC50 | = | 55.7 | nM | 7.25 |
| CHEMBL2178791 | — | IC50 | = | 80.9 | nM | 7.09 |
| CHEMBL2178777 | — | IC50 | = | 131.1 | nM | 6.88 |
| CHEMBL2178778 | — | IC50 | = | 167.8 | nM | 6.78 |
| CHEMBL2178780 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL2178782 | — | IC50 | = | 695.9 | nM | 6.16 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL2178776 | — | IC50 | = | 3920.0 | nM | 5.41 |