Assay Detail
Functional
CHEMBL2188989
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Cytotoxicity against human HCT116 cells after 48 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.51 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180855 | — | — | 1 | 7.05 |
| CHEMBL2180854 | — | — | 1 | 7.00 |
| CHEMBL2180862 | — | — | 1 | 6.82 |
| CHEMBL2180863 | — | — | 1 | 6.16 |
| CHEMBL2180844 | — | — | 1 | 6.00 |
| CHEMBL2180849 | — | — | 1 | 6.00 |
| CHEMBL2180852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180855 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2180854 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2180862 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2180863 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2180844 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2180849 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2180852 | — | IC50 | > | 25000.0 | nM | - |