Assay Detail
Binding
CHEMBL2189047
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Inhibition of bovine AChE after 120 mins by Ellman's method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.86 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217012 | — | — | 1 | 6.40 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 6.21 |
| CHEMBL2177714 | — | — | 1 | 5.92 |
| CHEMBL2177704 | — | — | 1 | 5.92 |
| CHEMBL2177716 | — | — | 1 | 5.25 |
| CHEMBL2177715 | — | — | 1 | 5.14 |
| CHEMBL2181475 | — | — | 1 | 5.13 |
| CHEMBL2177111 | — | — | 1 | 4.76 |
| CHEMBL2177700 | — | — | 1 | 4.72 |
| CHEMBL2177720 | — | — | 1 | 4.71 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 4.52 |
| CHEMBL2177705 | — | — | 1 | 4.42 |
| CHEMBL2177712 | — | — | 1 | 4.42 |
| CHEMBL2177699 | — | — | 1 | 4.40 |
| CHEMBL2177708 | — | — | 1 | 4.26 |
| CHEMBL2177698 | — | — | 1 | 4.23 |
| CHEMBL2177710 | — | — | 1 | 4.21 |
| CHEMBL2177702 | — | — | 1 | 4.21 |
| CHEMBL2177713 | — | — | 1 | 4.21 |
| CHEMBL2177703 | — | — | 1 | 4.17 |
| CHEMBL2177706 | — | — | 1 | - |
| CHEMBL2177701 | — | — | 1 | - |
| CHEMBL2177717 | — | — | 1 | - |
| CHEMBL2177707 | — | — | 1 | - |
| CHEMBL2177709 | — | — | 1 | - |
| CHEMBL2177718 | — | — | 1 | - |
| CHEMBL2177723 | — | — | 1 | - |
| CHEMBL2177721 | — | — | 1 | - |
| CHEMBL2177711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217012 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2177714 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2177704 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2177716 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2177715 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2181475 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2177111 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL2177700 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2177720 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL2177705 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL2177712 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL2177699 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL2177708 | — | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL2177698 | — | IC50 | = | 58700.0 | nM | 4.23 |
| CHEMBL2177710 | — | IC50 | = | 62300.0 | nM | 4.21 |
| CHEMBL2177702 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL2177713 | — | IC50 | = | 61600.0 | nM | 4.21 |
| CHEMBL2177703 | — | IC50 | = | 68100.0 | nM | 4.17 |
| CHEMBL2177706 | — | IC50 | = | 246000.0 | nM | - |
| CHEMBL2177701 | — | IC50 | = | 124000.0 | nM | - |
| CHEMBL2177717 | — | IC50 | = | 418000.0 | nM | - |
| CHEMBL2177707 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL2177709 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL2177718 | — | IC50 | = | 473000.0 | nM | - |
| CHEMBL2177723 | — | IC50 | > | 600000.0 | nM | - |
| CHEMBL2177721 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL2177711 | — | IC50 | = | 122000.0 | nM | - |