Assay Detail
Binding
CHEMBL2209185
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Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.67 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203548 | — | — | 1 | 5.64 |
| CHEMBL2203547 | — | — | 1 | 5.44 |
| CHEMBL2203543 | — | — | 1 | 5.21 |
| CHEMBL2203544 | — | — | 1 | 4.91 |
| CHEMBL1715925 | — | — | 1 | 4.90 |
| CHEMBL2203541 | — | — | 1 | 4.89 |
| CHEMBL2203539 | — | — | 1 | 4.78 |
| CHEMBL2203540 | — | — | 1 | 4.75 |
| CHEMBL2203546 | — | — | 1 | 4.65 |
| CHEMBL2203537 | — | — | 1 | 4.57 |
| CHEMBL1795371 | — | — | 1 | 4.52 |
| CHEMBL2203545 | — | — | 1 | 4.41 |
| CHEMBL491960 | CAMBINOL | — | 1 | 4.37 |
| CHEMBL1714005 | — | — | 1 | 4.33 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 4.33 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.33 |
| CHEMBL380797 | SIRTINOL | — | 1 | 4.31 |
| CHEMBL2203538 | — | — | 1 | 4.25 |
| CHEMBL2203542 | — | — | 1 | 4.17 |
| CHEMBL1591531 | — | — | 1 | - |
| CHEMBL420311 | — | — | 1 | - |
| CHEMBL270292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203548 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2203547 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2203543 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2203544 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL1715925 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL2203541 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL2203539 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL2203540 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL2203546 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL2203537 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1795371 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2203545 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL491960 | CAMBINOL | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL1714005 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 46600.0 | nM | 4.33 |
| CHEMBL265502 | SURAMIN | IC50 | = | 46600.0 | nM | 4.33 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL2203538 | — | IC50 | = | 55900.0 | nM | 4.25 |
| CHEMBL2203542 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL1591531 | — | IC50 | - | — | - | |
| CHEMBL420311 | — | IC50 | - | — | - | |
| CHEMBL270292 | — | IC50 | - | — | - |