Assay Detail
Binding
CHEMBL2209186
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Inhibition of recombinant SIRT3 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (CHEMBL4461) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.55 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1591531 | — | — | 1 | 5.43 |
| CHEMBL1715925 | — | — | 1 | 4.53 |
| CHEMBL2203543 | — | — | 1 | 4.52 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 4.52 |
| CHEMBL1795371 | — | — | 1 | 4.39 |
| CHEMBL2203546 | — | — | 1 | 4.36 |
| CHEMBL2203544 | — | — | 1 | 4.33 |
| CHEMBL420311 | — | — | 1 | 4.31 |
| CHEMBL270292 | — | — | 1 | - |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | - |
| CHEMBL491960 | CAMBINOL | — | 1 | - |
| CHEMBL2203539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1591531 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1715925 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL2203543 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1795371 | — | IC50 | = | 40300.0 | nM | 4.39 |
| CHEMBL2203546 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL2203544 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL420311 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL270292 | — | IC50 | - | — | - | |
| CHEMBL265502 | SURAMIN | IC50 | - | — | - | |
| CHEMBL491960 | CAMBINOL | IC50 | - | — | - | |
| CHEMBL2203539 | — | IC50 | = | 116300.0 | nM | - |