Assay Detail
Binding
CHEMBL2210358
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Binding affinity to 5-HT2B receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A σ(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.75 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205836 | — | — | 1 | 6.07 |
| CHEMBL2205813 | — | — | 1 | 5.65 |
| CHEMBL2205811 | — | — | 1 | 5.53 |
| CHEMBL2205815 | — | — | 1 | - |
| CHEMBL2205835 | — | — | 1 | - |
| CHEMBL2205834 | — | — | 1 | - |
| CHEMBL2205831 | — | — | 1 | - |
| CHEMBL2205830 | — | — | 1 | - |
| CHEMBL2205828 | — | — | 1 | - |
| CHEMBL2205818 | — | — | 1 | - |
| CHEMBL1779060 | — | — | 1 | - |
| CHEMBL1779059 | — | — | 1 | - |
| CHEMBL1779058 | — | — | 1 | - |
| CHEMBL602850 | — | — | 1 | - |
| CHEMBL608560 | — | — | 1 | - |
| CHEMBL2205822 | — | — | 1 | - |
| CHEMBL2205821 | — | — | 1 | - |
| CHEMBL2205820 | — | — | 1 | - |
| CHEMBL2205819 | — | — | 1 | - |
| CHEMBL2205826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205836 | — | Ki | = | 855.0 | nM | 6.07 |
| CHEMBL2205813 | — | Ki | = | 2254.0 | nM | 5.65 |
| CHEMBL2205811 | — | Ki | = | 2971.0 | nM | 5.53 |
| CHEMBL2205815 | — | Ki | - | — | - | |
| CHEMBL2205835 | — | Ki | - | — | - | |
| CHEMBL2205834 | — | Ki | - | — | - | |
| CHEMBL2205831 | — | Ki | - | — | - | |
| CHEMBL2205830 | — | Ki | - | — | - | |
| CHEMBL2205828 | — | Ki | - | — | - | |
| CHEMBL2205818 | — | Ki | - | — | - | |
| CHEMBL1779060 | — | Ki | - | — | - | |
| CHEMBL1779059 | — | Ki | - | — | - | |
| CHEMBL1779058 | — | Ki | - | — | - | |
| CHEMBL602850 | — | Ki | - | — | - | |
| CHEMBL608560 | — | Ki | - | — | - | |
| CHEMBL2205822 | — | Ki | - | — | - | |
| CHEMBL2205821 | — | Ki | - | — | - | |
| CHEMBL2205820 | — | Ki | - | — | - | |
| CHEMBL2205819 | — | Ki | - | — | - | |
| CHEMBL2205826 | — | Ki | - | — | - |