Assay Detail

CHEMBL2210779

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Functional

Inhibition of growth in wild type MEF cells after 6 days

ChEMBL ↗

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Target

MEF (CHEMBL614342) ↗

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Primary target MEF

CHEMBL614342

Anchored from Assay target.

Protein identity MEF

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	MEF
Confidence	1 — Organism
Curated By	Autocuration

Target

MEF (CHEMBL614342) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.

Cavell BE, Syed Alwi SS, Donlevy AM, Proud CG, Packham G.
J Nat Prod (2012) 75 : 1051 -1057
PubMed 22607231 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.33	5.33

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL151649	PHENETHYLISOTHIOCYANATE	—	1	5.33

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL151649	PHENETHYLISOTHIOCYANATE	IC50	=	4700.0	nM	5.33