Assay Detail

CHEMBL2211012

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Functional

Antitumor activity against human HCT15 cells assessed as inhibition of cell proliferation after 2 days by MTT assay

ChEMBL ↗

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Target

HCT-15 (CHEMBL612263) ↗

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Primary target HCT-15

CHEMBL612263

Anchored from Assay target.

Protein identity HCT-15

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HCT-15
Confidence	1 — Organism
Curated By	Autocuration

Target

HCT-15 (CHEMBL612263) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.

Porcelli L, Gilardi F, Laghezza A, Piemontese L, Mitro N, Azzariti A, Altieri F, Cervoni L, Fracchiolla G, Giudici M, Guerrini U, Lavecchia A, Montanari R, Di Giovanni C, Paradiso A, Pochetti G, Simone GM, Tortorella P, Crestani M, Loiodice F.
J Med Chem (2012) 55 : 37 -54
PubMed 22081932 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	4.58	4.77
Inhibition	2	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL479207	—	—	2	4.77
CHEMBL477119	—	—	2	4.68
CHEMBL408	TROGLITAZONE	4.0	1	4.29

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL479207	—	IC50	=	17000.0	nM	4.77
CHEMBL477119	—	IC50	=	21000.0	nM	4.68
CHEMBL408	TROGLITAZONE	IC50	=	50900.0	nM	4.29
CHEMBL477119	—	Inhibition		-	%	-
CHEMBL479207	—	Inhibition		-	%	-