Assay Detail
Binding
CHEMBL2211270
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat NET
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.10 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 8.41 |
| CHEMBL2206509 | — | — | 1 | 8.20 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL2206509 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 20.0 | nM | 7.70 |