Assay Detail
Binding
CHEMBL2212124
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Binding affinity to TRalpha1
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.29 | 7.75 |
| Ki | 2 | 6.52 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41036 | — | — | 1 | 8.14 |
| CHEMBL2203702 | — | — | 1 | 7.75 |
| CHEMBL235788 | — | — | 1 | 6.82 |
| CHEMBL471897 | MB07811 | 2.0 | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41036 | — | Ki | = | 7.18 | nM | 8.14 |
| CHEMBL2203702 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL235788 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL471897 | MB07811 | Ki | = | 12500.0 | nM | 4.90 |