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Assay Detail

CHEMBL2212129

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at human TRalpha1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Thyroid hormone receptor alpha (CHEMBL1860)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia.
Joharapurkar AA, Dhote VV, Jain MR.
J Med Chem (2012) 55 : 5649 -5675
PubMed 22512468 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.70 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL112087 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL112087 Kd = 200.0 nM 6.70