Assay Detail
Functional
CHEMBL2213346
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Cytotoxicity against human MES-SA/Dx5-Rx1 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Atom-based enumeration: new eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.94 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2208112 | — | — | 1 | 9.04 |
| CHEMBL2208113 | — | — | 1 | 8.68 |
| CHEMBL2208109 | — | — | 1 | 8.55 |
| CHEMBL2208111 | — | — | 1 | 8.32 |
| CHEMBL2208114 | — | — | 1 | 8.25 |
| CHEMBL2208108 | — | — | 1 | 8.19 |
| CHEMBL2208110 | — | — | 1 | 7.00 |
| CHEMBL1683544 | ERIBULIN MESYLATE | 4.0 | 1 | 5.51 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2208112 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL2208113 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2208109 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2208111 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2208114 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2208108 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2208110 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1683544 | ERIBULIN MESYLATE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 1000.0 | nM | - |