Assay Detail
Binding
CHEMBL2213717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV genotype 1b BK NS3/4A protease D168V mutant expressed in Escherichia coli incubated for 30 mins by time-resolved fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate BK) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.77 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203892 | — | — | 1 | 8.92 |
| CHEMBL2203882 | — | — | 1 | 8.74 |
| CHEMBL2203873 | — | — | 1 | 8.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203892 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2203882 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2203873 | — | Ki | = | 2.2 | nM | 8.66 |