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Assay Detail

CHEMBL2214303

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against vincristine-resistant human HL60/Vinc cells incubated for 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Autocuration

Publication

Antiproliferative activity of salinomycin and its derivatives.
Huczyński A, Janczak J, Antoszczak M, Wietrzyk J, Maj E, Brzezinski B.
Bioorg Med Chem Lett (2012) 22 : 7146 -7150
PubMed 23079523 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.23 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.04
CHEMBL1208572 SALINOMYCIN 2.0 1 5.46
CHEMBL2047977 1 5.37
CHEMBL2047973 1 5.37
CHEMBL2207532 1 5.28
CHEMBL2047974 1 5.28
CHEMBL2047976 1 5.22
CHEMBL2207533 1 5.16
CHEMBL2207534 1 4.55
CHEMBL2047978 1 4.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 910.0 nM 6.04
CHEMBL1208572 SALINOMYCIN IC50 = 3440.0 nM 5.46
CHEMBL2047977 IC50 = 4310.0 nM 5.37
CHEMBL2047973 IC50 = 4310.0 nM 5.37
CHEMBL2207532 IC50 = 5250.0 nM 5.28
CHEMBL2047974 IC50 = 5310.0 nM 5.28
CHEMBL2047976 IC50 = 6020.0 nM 5.22
CHEMBL2207533 IC50 = 6870.0 nM 5.16
CHEMBL2207534 IC50 = 28080.0 nM 4.55
CHEMBL2047978 IC50 = 29110.0 nM 4.54