Assay Detail

CHEMBL2214341

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Functional

Antagonist activity at glucocorticoid receptor by cellular reporter gene assay

ChEMBL ↗

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Target

Glucocorticoid receptor (CHEMBL2034) ↗

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Primary target Glucocorticoid receptor

CHEMBL2034

Anchored from Assay target.

Protein identity Glucocorticoid receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Glucocorticoid receptor (CHEMBL2034) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.

McComas C, Cohen J, Huselton C, Marella M, Melenski E, Mugford C, Slayden O, Winneker R, Wrobel J, Yudt MR, Fensome A.
Bioorg Med Chem Lett (2012) 22 : 7119 -7122
PubMed 23079530 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.92	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL267431	ASOPRISNIL	3.0	1	6.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL267431	ASOPRISNIL	IC50	=	120.0	nM	6.92