Assay Detail
Binding
CHEMBL2214360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GAL4-fused PPARalpha ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene transactivation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.95 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479207 | — | — | 1 | 8.52 |
| CHEMBL2206302 | — | — | 1 | 7.60 |
| CHEMBL477312 | — | — | 1 | 7.52 |
| CHEMBL477119 | — | — | 1 | 7.25 |
| CHEMBL2206304 | — | — | 1 | 6.91 |
| CHEMBL2206303 | — | — | 1 | 6.21 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 5.80 |
| CHEMBL2206305 | — | — | 1 | 5.76 |
| CHEMBL153057 | — | — | 1 | - |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | - |
| CHEMBL2206306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479207 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2206302 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL477312 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL477119 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2206304 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL2206303 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL295416 | PIRINIXIC ACID | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2206305 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL153057 | — | EC50 | - | — | - | |
| CHEMBL121 | ROSIGLITAZONE | EC50 | - | — | - | |
| CHEMBL2206306 | — | EC50 | - | — | - |